Lung adenocarcinoma can usually cause painful wheezing. Lung adenocarcinoma is a malignant disease caused by smoking, air pollution, occupational hazards, chronic lung diseases, hereditary factors, etc. Cancer cells usually originate from the epithelium of the bronchial mucosa or the mucosal glands of the large bronchial tubes and other parts of the lung, which belongs to a type of non-small cell lung cancer. Lung adenocarcinoma usually presents uncomfortable symptoms such as mild paroxysmal, irritating cough, and indirect or persistent blood in sputum. In addition to these symptoms, it may also cause painful wheezing, which requires timely consultation for treatment. If lung adenocarcinoma is in the early stage, with limited lesions or only hilar lymph node metastasis, lobectomy with hilar mediastinal lymph node dissection can be chosen under doctor’s guidance. If the lung adenocarcinoma is in the middle stage or above, after radical surgery, radiotherapy and chemotherapy are also needed. When symptoms of wheezing pain appear, it is recommended to consult a doctor in time and carry out standardized treatment under the doctor’s guidance after the cause of the disease is clarified, so as to avoid delaying the condition.