Mouth ulcers pain can not sleep, you can use analgesic drugs, such as 1% procaine, 2% lidocaine or 0.5% dacronine solution, can play the effect of pain, can be sprayed on the surface of mouth ulcers, so that the mucous membrane of the ulcers to produce a numb feeling. Mouthwash can also be used, such as compound chlorhexidine gargle, compound boric acid solution, compound tinidazole solution, to promote the normalization of the bacterial flora in the mouth, which is conducive to the healing of oral ulcers; at the same time, applying drugs to promote healing, such as tretinoin ointment, recombinant human epidermal growth factor gel or topical solution, watermelon cream spray, stomatitis spray, to promote the healing of ulcers, and to play a role in reducing the effect of pain; Pain medications, such as acetaminophen or ibuprofen, may also be used if the pain is particularly severe.