After the age of 80, if you are in good physical condition and suspect the presence of intestinal tumors and other diseases, you can consider having a colonoscopy, but if you are in poor physical condition and may not be able to tolerate a colonoscopy, a colonoscopy is usually not recommended. Enteroscopy is the insertion of a colonoscope through the anus and along the intestinal lumen to the ileocecal region to observe the intestinal mucosa for the presence of inflammation, polyps, tumors, and other lesions, and at the same time, biopsies can be taken for pathological examination to clarify the type of disease. However, colonoscopy is an invasive examination, which may cause some damage to the intestinal mucosa and may cause abdominal discomfort such as abdominal pain and distension. For elderly people after the age of 80, if they are in relatively good physical condition and can tolerate colonoscopy after assessment by a doctor, colonoscopy can be considered when there is a high suspicion of the presence of intestinal neoplastic diseases, in order to clarify whether it is a malignant tumor and to guide the next step of treatment. However, if the patient’s physical condition is poor or more serious cardiopulmonary disease exists and he/she is unable to tolerate colonoscopy, colonoscopy is usually not recommended in order to avoid irritation and aggravation of the patient’s condition. Whether colonoscopy is necessary after the age of 80 should be decided after a comprehensive assessment by a doctor.