Urethral pain requires the choice of medication according to the cause of the disease. Causes of urethral pain include urinary tract infections, urinary stones, etc., and patients can choose levofloxacin, allopurinol and other drugs for treatment. However, if the urethral pain is caused by tumor, taking medicine is usually ineffective and may require surgical treatment. 1. Urinary tract infection: this kind of patients due to bacteria and other pathogens along the urinary tract for retrograde infection, can lead to patients with symptoms of urinary pain, this time the need for anti-infection treatment, commonly used drugs, including levofloxacin, ceftriaxone sodium, etc., in addition to the use of sodium bicarbonate alkalinization of urine to relieve symptoms. 2. Urinary stones: patients due to stone obstruction, can lead to urinary pain during urination, at this time the patient can choose allopurinol and other drugs for lithotripsy, part of the conservative treatment is ineffective patients may need to choose extracorporeal lithotripsy treatment. 3. Urological tumors: patients with malignant tumors will also have urethral pain, at this time, patients can choose surgery to remove the tumor, and with chemotherapy to prevent tumor metastasis and recurrence. Patients with urethral pain need to consult the doctor in time to prevent the deterioration of the condition. Drugs should be applied under the guidance of the doctor.