Mouth ulcers generally refers to mouth ulcers, elimination methods are local treatment, systemic treatment, etc., the use of medication should follow the doctor’s instructions. 1. Local treatment: (1) anti-inflammatory drugs: there are 0.1% tretinoin ointment, 0.1% potassium permanganate solution, cediriodine tablets, tin analogs, and even can be used to make a film of gentamycin, surface anesthetics, corticosteroids, etc. to cover the ulcer surface and reduce pain. (2) Analgesic drugs: such as lidocaine gel, spray and benzocaine gel, etc., only when the pain is intolerable or affects eating, can quickly anesthetize the pain. (3) Local closure: submucosal closure injections to treat persistent or painful ulcers can relieve pain and promote healing, commonly used drugs are trimethoprim or prednisolone acetate suspension added to 2% lidocaine solution. (4) Physical therapy: intraoral ultraviolet irradiation or the use of lasers, microwaves and other therapeutic devices can help reduce exudation and promote healing. 2. Systemic therapy: (1) Glucocorticosteroids and other immunosuppressants: glucocorticosteroids can be anti-infective, anti-allergic, and reduce inflammatory exudation, etc. Commonly used drugs are prednisone, etc. Immunosuppressants have an anti-infective effect, and commonly used drugs are cyclophosphamide, methotrexate, etc. Pay attention to the adverse effects of the two types of drugs in long-term users. (2) immune enhancers: can have to enhance the body’s cellular immune function, commonly used drugs such as levamisole, etc., gammaglobulin, etc., is suitable for people with reduced humoral immune function. (3) Other: such as glutamine to stabilize mood, reduce insomnia, appropriate supplementation of vitamins and trace elements. If ulcers appear in the mouth, it is recommended to actively carry out the treatment, the use of drugs need to follow the doctor’s instructions.