Nephritis protein two plus sign that is urine protein (++), refers to the urine protein qualitative test is positive in routine urine testing, the protein in the urine is about 1~3g/24h, is considered to be a moderate amount of proteinuria. Urine protein (++), the most common disease is a variety of nephritis, including acute nephritis, chronic nephritis, lupus nephritis, purpura nephritis, and diabetic nephropathy. As the disease progresses, urine protein gradually increases, and even symptoms such as hypoproteinemia and edema appear. When urine protein (++) is found, further urine microalbumin, or 24-hour quantitative urine protein monitoring is needed to clarify the specific level of urine protein. Combined with blood biochemical tests, liver function, renal function, plasma albumin, total protein, lipid testing. If necessary, combined with renal pathology biopsy, to understand the cause of the disease, as well as the severity of pathological damage. It is recommended that patients with nephritis who have two plus signs of urinary protein should go to the hospital in time, and under the guidance of the doctor, actively improve the relevant examinations to clarify the causes and actively treat the disease.