Bone pain after leukemia chemotherapy can be targeted analgesia, treatment of primary leukemia, discontinuation of granulocyte colony-stimulating factor. The causes of bone pain after leukemia chemotherapy include high tumor load and hematopoietic recovery. 1. Leukemia patients generally have abnormally high white blood cell values, leukemia cells are tumor cells, if the disease is not relieved after chemotherapy, high tumor load will lead to bone pain, mainly manifested as severe pain. The chemotherapy regimen can be changed to treat leukemia, to reduce the tumor load, and the pain can be severely analgesic with aminophenol hydrocodone and morphine. 2. Another complication of chemotherapy is myelosuppression, which is usually treated with granulocyte colony-stimulating factor (GCSF). After the application of this drug, the white blood cells will rebound, and when the suppression period is over and hematopoiesis recovers, bone pain will occur, which can be discontinued, and pain-relieving treatment can be carried out, including aminophenol hydrocodone, ibuprofen, etc. All of the above drugs should be prescribed by a doctor. All of the above medications should be used under medical supervision.