There are very many causes of hepatosplenomegaly, such as hepatitis, cirrhosis, chronic anemia, infectious diseases and so on. 1. Hepatitis: Chronic hepatitis, viral hepatitis and other diseases, due to inflammatory stimulation, can cause liver and spleen enlargement, which may also be accompanied by liver pain. As an immune organ, the spleen may also become enlarged when the body is infected by inflammation. 2. Cirrhosis: Liver and spleen enlargement will appear in the early stage of cirrhosis, which is the main symptom of cirrhosis. The liver of patients with cirrhosis is harder overall, with sharper edges, and the surface will show unevenness. 3. Chronic anemia: Anemia can also cause hepatosplenomegaly, and there are many causes of anemia, such as iron deficiency anemia, aplastic anemia, etc. 4. Infectious diseases: schistosomiasis, dysentery, malaria, rubella virus, black fever and many other infectious diseases, patients may also have hepatosplenomegaly. There are many reasons that lead to hepatosplenomegaly, after the symptoms appear, it is recommended that patients go to the hospital in time to improve the examination, clear diagnosis, and give targeted treatment after identifying the cause.