Small granules at the corner of the eyes may be caused by cornu rashes, whitehead pimples, sweat duct tumors and other diseases, which need to take general measures, medication, other treatments and surgical treatments for the cause of the disease. 1. Corns: mainly manifested as hard yellowish-white pimples on the eyelids and under the eyes, patients can use sterilized needles to pick through the epidermis and squeeze out small yellowish-white particles under the operation of doctors, and laser ablation and electrodesiccation methods can also be adopted. 2. Whitehead acne: Typically characterized by milky-white papules on the face, which can be manifested as small particles in the corners of the eyes. Patients need to maintain a happy mood, keep the face clean, follow the doctor’s instructions for local use of isotretinoin gel, 0.1% adapalene gel and other retinoic acid drugs, or 2.5%, 5% benzoyl peroxide. Can also take fruit acid peeling, photodynamic, photon therapy and other physical therapy. 3. Sweat duct tumor: it often occurs around the eye socket, and localized normal skin color, tawny or yellowish flat papules will appear. Some patients who feel that it affects their aesthetics can be treated with electrocautery, radiofrequency, carbon dioxide laser or cryotherapy. It is recommended that patients with small particles in the corners of the eyes go to the hospital to clarify the specific cause and cooperate with the doctor for active treatment if necessary.