The main method for the disappearance of lupus erythematosus rash is to follow the doctor’s prescription for local and systemic medication, but the rash may be prone to recurrence. Lupus erythematosus is categorized into cutaneous lupus erythematosus and systemic lupus erythematosus, and patients may have symptoms such as erythema, rash, fatigue, fever, etc. The symptoms of lupus erythematosus such as erythema and rash can be relieved by topical and systemic medications. Topical medications include topical glucocorticoids, calcium-modulated phosphatase inhibitors, and retinoids. Topical glucocorticosteroids such as dexamethasone ointment, calcium-modulated phosphatase inhibitors such as pimecrolimus cream, and retinoids such as retinoic acid cream. Systemic medications include antimalarials such as hydroxychloroquine, glucocorticosteroids such as prednisone acetate tablets, immunosuppressants such as thalidomide and cyclophosphamide, and biologics such as belimumab. Drugs should be used under the guidance of a physician, and it is recommended that patients with lupus erythematosus who develop a rash go to the rheumatology and immunology department or the dermatology department of a regular hospital for standardized treatment under the guidance of a physician and regular follow-up.