Treatment methods for advanced lung cancer include targeted drug therapy, systemic chemotherapy, immunotherapy, radiotherapy and palliative surgery. 1. Targeted drug therapy: Targeted drugs can specifically act on the specific location of tumor cells and can highly selectively kill tumor cells. Patients with advanced stage of lung adenocarcinoma and squamous lung cancer can improve the genetic test, and if they have positive driver genes, such as common gene mutations of EGFR, ALK, ROS1, etc., they can orally take corresponding targeted drugs for precise treatment. 2. Systemic chemotherapy: platinum-containing double-drug chemotherapy is the cornerstone of lung cancer treatment. In the advanced stage of small cell lung cancer, etoposide/irinotecan + platinum regimen is often used, while in non-small cell lung cancer, pemetrexed/gemcitabine/docetaxel/paclitaxel + platinum regimen is often used. 3. Immunotherapy: immunotherapy is to activate the body’s own lymphocytes to kill the tumor. According to the expression of PD-L, it can be decided whether to use immunotherapy alone or immunotherapy combined with chemotherapy. Common immunotherapy drugs include pembrolizumab, atilizumab, sindilizumab and so on. 4. Radiotherapy: it is to use rays to kill tumor cells. The dose and scope of local radiotherapy can be selected according to the location, size and pathological type of the lesion in advanced stage of lung cancer. 5. Palliative surgery: palliative surgery is symptomatic rather than radical surgery, which can relieve patients’ pain and improve their quality of life. Precautions: The treatment of advanced lung cancer needs to be based on the patient’s physical ability score, pathological type and other conditions to formulate a comprehensive treatment plan, and it is necessary to consult regular hospitals and follow the doctor’s instructions.