Prevention of monkeypox virus includes avoiding contact with any wild primates and getting vaccinated against smallpox if necessary. Monkeypox is a zoonotic disease caused by the monkeypox virus, and its symptoms are similar to those of smallpox caused by the smallpox virus. The two are close relatives in terms of genetic factors, but the lethality and infectiousness of monkeypox is much lower than that of smallpox virus. According to the information published by the World Health Organization, monkeypox virus is mainly transmitted by contact, in which contact with infected animals poses the greatest risk, especially contact with infected monkeys on the skin, respiratory tract, or wounds around the eyes, or mucous membranes of the nose and mouth. In order to better prevent the spread of monkeypox virus to humans, we need to avoid contact with any wild primates in areas where there are outbreaks, and although monkeypox is not easily transmitted between people, close contact with infected people may also be a possibility of infection. At the same time, stay away from the infected area and urge patients with fever, chills, headache, muscle aches, back pain, swollen lymph nodes, etc. to seek medical attention and avoid close contact with the infected person. In addition, smallpox vaccine can be administered, which also has a high immunity to monkeypox virus.