High globulin is mostly considered to be caused by systemic lupus erythematosus, viral hepatitis, cirrhosis and other diseases, which need to be selected according to the cause of the drug treatment, such as glucocorticoids, immunosuppressants, nucleoside analogs, antiviral drugs and other drugs. 1. Systemic lupus erythematosus (SLE): high globulin is considered to be caused by SLE. If patients are diagnosed with SLE, they should take oral glucocorticosteroids, such as prednisone, hydrocortisone, dexamethasone, etc., or oral immunosuppressants, such as azathioprine and methotrexate, as prescribed by the doctor. 2. Viral hepatitis: high globulin may also be caused by viral hepatitis, patients can follow the doctor’s instructions to use medication. Patients can take oral nucleoside analogs, such as lamivudine, telbivudine, tenofovir, eminofovir and so on. 3. Cirrhosis: high globulin is also considered to be caused by cirrhosis, the patient under the guidance of the doctor to take oral medication. Such as interferon alpha, tenofovir, entecavir and other antiviral drugs. After treating the primary disease, the high globulin can be relieved. There are many reasons that lead to high globulin, we suggest that patients clarify the cause of the disease and actively cooperate with the doctor to take appropriate drug treatment.