Hypertensive patients due to long-term elevated blood pressure or poor control, easy to cause complications, that is, renal insufficiency, as well as the combination of urinary protein and so on. Generally, patients with hypertension combined with renal insufficiency and urinary protein, the main choice of drugs is ACEI or ARB drugs, most of them will choose irbesartan, valsartan and other ARB drugs. However, severe renal insufficiency, blood creatinine greater than 3mg/dL is not recommended to apply this class of antihypertensive drugs, if you have to apply, you need to monitor creatinine and blood potassium levels. In severe renal insufficiency, calcium channel antagonists such as nifedipine or alpha receptor antagonists may be used. Patients with hypertension with renal insufficiency should have more stringent blood pressure control goals, which should generally be below 130/80 mmHg.