Messy hand lines are usually caused by vitamin deficiencies, low immunity, and heavy physical labor. 1. Lack of vitamins: patients may be due to a lack of vitamins which leads to keratinization of epithelial cells, messy hand lines, dryness, roughness and scaling. 2. Malnutrition: When the patient is in the state of long-term malnutrition, the patient may appear skin malnutrition, hand lines messy situation. 3. Heavy physical labor: when the patient has messy hand lines, such as the formation of acquired, need to consider whether due to manual operation or some heavy physical labor, do not pay attention to the care of the hands, resulting in messy hand lines. In addition, the appearance of messy hand lines may also be hereditary, chapped hands and feet and other reasons. If the messy hand lines are accompanied by other discomforts, it is recommended that the patient go to the hospital in time to clarify the cause, and if the cause is pathologic, relevant treatments will be carried out.