Significant swelling and hardening of the lower leg with pain can be seen in the following diseases: first, simple varicose veins of the lower extremity with a long history of disease, local formation of phlebitis, lack of oxygen in the soft tissues of the lower extremity skin, and even significant ulcer formation and liposclerosis, so the patient will show pain and local hardening. The activity will lead to swelling as well as discomfort of the lower limbs aggravated, and in serious cases, surgery is needed to be chosen, and the occurrence of varicose veins is related to long time upright position, strain, and also the lower limb valve insufficiency, and there is also a certain family genetic tendency. Secondly, there are some patients with lymphoma caused by diseases of the lymphatic system of the lower extremities, which may also manifest as obvious swelling, restricted activity and aggravation after activity, commonly with pelvic tumors or occupying lesions in the groin area, and also with congenital developmental abnormalities, which can be solved by surgical treatment if necessary.