Calf swelling may be related to physiological edema, local trauma, vascular disease, cardiac and renal insufficiency, hypothyroidism, etc. It is necessary to clarify the cause of the disease and then give targeted elevation of the legs, cold or hot compresses, medication, surgical treatment, and so on. 1. Physiological edema: when traveling for a long time, due to prolonged sitting, can cause poor venous return of the lower limbs, calf swelling symptoms, can elevate the lower limbs to rest, the symptoms can generally be relieved on their own. 2. Local trauma: if the calf is affected by external force, resulting in local soft tissue injury, or even fracture, there may be calf swelling, pain, activity disorders and so on. Cold compresses within 72 hours after soft tissue injury and intermittent hot compresses after 72 hours can help reduce swelling. And oral ibuprofen, diclofenac sodium anti-inflammatory pain as prescribed by the doctor. If there is a fracture, the affected limb needs to be braked and fixed with plaster, and serious fracture needs to be fixed after surgical incision. 3. Vascular disease: lower extremity arterial vein thrombosis, phlebitis and other diseases, can lead to calf swelling, pain, usually for one side of the calf onset. Anti-inflammatory and anticoagulant treatments should be carried out after the cause of the disease is clarified. 4. Cardiac and renal insufficiency: depressed edema of the lower limbs can occur. It is necessary to actively treat the primary disease, and cardiac insufficiency can be treated with cardiotonic and diuretic drugs such as digoxin and furosemide, etc. Renal insufficiency should be treated with symptomatic treatment, and dialysis treatment should be carried out if necessary. 5. Hypothyroidism: it can lead to mucous edema of the calf, and can be treated with levothyroxine tablets. Swelling of the calves, we should consult a doctor in time, after the cause of the disease is clear and active treatment, the use of drugs need to follow the doctor’s instructions.