There are many different types of connective tissue diseases, and the characteristics of symptoms, severity and prognosis of different diseases are different, and there is a large difference in life expectancy. Connective tissue diseases have a long course, complex conditions, and are prone to combine multiple systems and multiple organ damage, among which the more harmful diseases, such as systemic lupus erythematosus, can cause impossible damage to important organs of the organism, and the condition is heavy and has a certain degree of lethality. Although dry syndrome can also invade multiple systems of human body, but generally the symptoms are light, the disease progresses slowly and the prognosis is good, and some patients even don’t know they have the disease for the rest of their lives. However, no matter what kind of connective tissue disease they are suffering from, with the progress of medical treatment and the development and application of new drugs, under systematic and standardized treatment, most patients with connective tissue disease can be in long-term stability and remission, and work and live like normal people. Even for patients with SLE, the current 10-year survival rate has reached more than 90%, and the 15-year survival rate can reach more than 80%. However, it should be noted that for some patients with acute onset and rapid progression, the disease is more aggressive and still has a certain mortality rate. Therefore, early diagnosis and systematic treatment are the keys to ensure the stability of connective tissue disease. Patients also need to maintain a good and healthy state of mind and establish self-confidence in treatment.