Inflammation of mesenteric lymph nodes and night sweating in children is mainly due to abdominal pain, which is a normal phenomenon. Inflammation of mesenteric lymph nodes in children is mainly caused by viral infections, bacterial infections, low immunity, poor living environment, and Mycoplasma pneumoniae, parasites, and lymphomas. Children’s lymphatic system is not yet mature, and the barrier function is relatively poor, so respiratory and gastrointestinal infections will involve the mesentery, thus causing the emergence of the disease. The main clinical manifestations are abdominal pain, vomiting, fever, accompanied by diarrhea, constipation and other symptoms. Children with prolonged abdominal pain and vomiting may suffer from weight loss and insufficient nutritional intake. Parents are advised to take their children to regular hospitals in time, under the diagnosis of doctors, according to the specific conditions of the children, targeted treatment, to drink more water, to maintain a normal electrolyte balance.