The causes of periampullary carcinoma are still not completely clear, but some researches show that smoking, hepatitis B and alcohol consumption may be the risk factors for the development of periampullary carcinoma. At present, the cause of periampullary carcinoma is still unclear, but relevant research data indicate that smoking, hepatitis B and alcohol consumption may be the risk factors for the development of periampullary carcinoma. Typical symptoms of periampullary carcinoma include jaundice, gastrointestinal bleeding, abdominal pain, etc. The main treatment means of this disease is surgery, and the most commonly used surgical method is pancreaticoduodenectomy. As periampullary carcinoma is easy to detect, the probability of surgical resection in early stage is high, and the long-term prognosis of patients after surgery is relatively good, and the 5-year survival rate after surgery can reach 40%~50%. It should be noted that patients with periampullary carcinoma can reduce the adverse effects of the disease through “early detection, early diagnosis and early treatment”, and many of them may survive for a long period of time, so it is suggested that patients should establish confidence in treatment.