Hepatitis B vaccine pain is not very noticeable because it is taken with a small 1mL syringe and is a deep intramuscular injection that is better absorbed. In the first day after vaccination, there may be a slight hidden pain, and most of the muscle pain will disappear completely in the second day. Hepatitis B vaccine causes relatively few systemic symptoms such as fever after vaccination, which is the most effective way of preventing Hepatitis B. The procedure for hepatitis B vaccination is as follows. The procedure of hepatitis B vaccination is 0, 1, 6 months, healthy babies weighing more than 5 pounds after birth should be vaccinated within 24h, and liver function and hepatitis B five items should be rechecked 3 months after vaccination.