Prof. Tang Shaofei, 62 years old, is a retired teacher of a famous university. Before retiring, Prof. Tang has always had a wish, that is, to travel all over the north and south of the Yangtze River, set foot on the famous mountains and rivers of the motherland, with a camera to record the most beautiful moments in their own minds. But who knows, just after the retirement formalities, the bag is not yet fully prepared, Professor Tang felt his right hand is a little bit wrong, always involuntarily trembling, writing is getting smaller and smaller, can not carry out the fine movements, at first he did not take it seriously. One day, he took a few pictures of his little grandson, and when he played them back, he inadvertently discovered that nine out of ten of them had double images, which made Prof. Tang frustrated. Careful companion found that he not only arm some trembling, even walking are no longer the previous speedy step like the wind, the gait is increasingly heavy, action is more and more slow, and finally developed to life can not take care of themselves. With no other choice, Prof. Tang came to the Third Affiliated Hospital of the Southern Medical University accompanied by his partner, and Prof. Liu Chengyong, Director of Neurosurgery, personally diagnosed and treated him. After examination, Prof. Tang suffered from typical Parkinson’s disease. After systematic medication, his symptoms were relieved, but later on, his symptoms continued to worsen and he showed signs of intolerance to medication. Finally, Prof. Tang underwent “brain pacemaker” surgery at the Third Affiliated Hospital, and after the surgery, Prof. Tang’s symptoms improved significantly, and he could take care of his own life again. Prof. Liu explained that Parkinson’s disease is also known as “tremor paralysis”. Parkinson’s disease, also known as “tremor paralysis”, is a neurodegenerative disease common in middle-aged and elderly people, and develops mostly after the age of 60. It is characterized by slow movements, tremors in the hands and feet or other parts of the body, loss of coordination of the limbs, and increasing stiffness. The onset of Parkinson’s disease is slow and the initial symptoms often go unnoticed, and many middle-aged and elderly people suffer from Parkinson’s disease without realizing it. At present, this disease, known as the “third killer” of the middle-aged and the elderly, is troubling many patients and their families. According to a recent epidemiological survey confirmed that the world’s 4 million patients in 1.7 million people in China, Parkinson’s has become the middle-aged and elderly “third killer”, and increasingly younger. Among them, the proportion of intellectuals suffering from Parkinson’s disease is slightly higher than the rest of the population, and is growing. The etiology of the disease is still unclear, and current research shows that its onset is related to a combination of factors such as ageing-induced degenerative changes in the nervous system, genetics, and exposure to environmental toxins. Industrial and agricultural pollution, indoor decoration pollution, cell phones, computer radiation, etc. may be a potential cause of Parkinson’s disease, 20% of patients due to environmental pollution or erosion of chemical toxins “hit”. Therefore, to control Parkinson’s disease, the most important thing is early prevention, early detection and early treatment, in order to delay the occurrence and progress of the disease. Prof. Liu believes that the early symptoms of Parkinson’s disease can be observed, usually starting from the distal part of one side of the upper limb, mainly the thumb, index finger and middle finger, which manifests as involuntary movements of the fingers like rubbing pills or counting banknotes. Then it gradually extends to the lower limbs of the same side and the opposite side of the limbs, and in the late stage, it can spread to the jaw, lips, tongue and head, which is the most important feature of Parkinson’s disease tremor; the limbs and body of Parkinson’s disease patients usually lose their suppleness, and become very stiff. The early stages of the disease tend to begin in one limb. Initially, a limb feels inflexible and stiff, and gradually worsens, with bradykinesia and difficulty in performing even everyday actions. In the early stage, due to the ankylosis of the upper arm muscles and finger muscles, the patient’s upper limbs are often unable to make fine movements, such as untieing shoes and buttons, etc., which become much slower than before, or can not be completed successfully. Writing also gradually becomes difficult, and the handwriting is curved and becomes smaller and smaller, which is known as “micrographia” in medicine. Facial muscle movement decreases, the patient rarely blinks, the rotation of the eyes decreases, and the expression is dull, as if wearing a mask, which is medically known as “mask face”. Speech is reduced and the voice is low and monotonous. In severe cases, this can lead to choking on food and water. In the late stage of the disease, the patient cannot stand up by himself after sitting down, cannot turn over by himself after lying down, and cannot take care of himself in daily life; although all the muscles of the whole body can be involved and the muscle tension is increased, the tension of flexor muscle is higher than that of extensor muscle at rest, so the patient has a special posture: the head is tilted forward, the torso is slightly flexed, the upper arm is inwardly retracted, the elbow is flexed, the wrist is slightly stretched out, the finger-palm joint is flexed while the interphalangeal joints are straightened, and the thumb is opposite to the palm, and the hip and knee joints are mildly flexed. . Prof. Liu said that Parkinson’s disease is caused by a decrease in the number of substantia nigra cells in the brain. The substantia nigra cells are able to produce dopamine like a processing plant. If the processing plant is destroyed, the dopamine in the brain will be reduced and another part of the brain, the pallidum, will be abnormally active, which is the main cause of Parkinson’s disease. So far, surgical treatments for Parkinson’s disease are mainly two ways: neuronal nucleus pulposus cell destruction surgery and deep brain electrical stimulation surgery. The former is to create a destruction foci with a diameter of about 3 mm on the abnormally active nucleus pulposus, while the latter is to implant a stimulator to achieve a similar destruction effect through high-frequency electrical stimulation, but without causing damage to the neural tissues. In terms of surgical techniques, there is not much difference between the two, as electrodes are placed on specific targets in the brain’s inner nuclei, which are then stimulated or destroyed. However, Parkinson’s disease is a chronic progressive disease, as the disease continues to worsen, the symptoms will reappear, by changing the parameters of the electrical stimulation can make the patient’s symptoms once again relief, so the deep brain electrical stimulation can make the patient’s symptom relief for a longer period of time. Prevention of all diseases is the first priority, and the key question is whether it is appropriate and effective. Prof. Liu believes that prevention and treatment of cerebral atherosclerosis is the fundamental measure to prevent Parkinson’s disease, clinically, we should seriously treat hypertension, diabetes, hyperlipidemia; at the same time, we should avoid or reduce the exposure to toxic substances to the human nervous system, such as carbon monoxide, carbon dioxide, manganese, mercury, etc.; and we should avoid or reduce the application of the drugs such as fenestrazine, lisinopril, chlorpromazine, etc., which induced the tremor paralysis; in addition, we should also strengthen the physical and mental activity to retard the cerebral nervous system. In addition, it is necessary to strengthen sports and brain activities to slow down the aging of brain and nerve tissues. How to exercise effectively for Parkinson’s disease patients, Prof. Liu suggests that adhering to moderate exercise is beneficial for Parkinson’s disease, including aerobic exercise, i.e. small and medium exercise endurance exercise, including outdoor jogging or jogging on treadmill, stretching exercise, such as some stretching exercise movements in broadcasting gymnastic exercises, and strength exercise, such as strength exercise using dumbbells and other equipment. In addition, tai chi is recommended because it is good for developing a sense of balance. For patients in the middle and late stages of the disease, it is very important to be careful to prevent falls and other accidental protection, such as jogging can be used with a four-point support with pulleys walker, treadmill jogging in the upper to suspend the protective belt, the lower end of the body tied to prevent falls. 20-30 minutes per day or every other day. Although trembling is a warning sign of Parkinson’s disease, there are about 30% of patients whose early symptoms are not just shaking hands and feet, but may be that their hands and feet become heavy and disobedient, they can’t move well, and their legs don’t move when they walk. Therefore, Prof. Liu reminds friends: a little attention from yourself and your family can benefit the whole family, if you find your family meets many of the above symptoms, please go to a standardized specialist hospital as soon as possible to receive treatment.