Squeezing pimples within the danger triangle of the face may lead to the development of intracranial infections. Pimples, also known as acne, are an inflammatory reaction of the skin caused by high sebum production, which leads to blockage of the openings of the hair follicles. If squeezed by hand, the hand carries a large amount of bacteria, which may aggravate the skin infection. The facial danger triangle is the triangular area formed by the line from the root of the nose to the corners of the mouth on both sides. The veins in this area lack venous valves, and at the same time, the blood vessels in this area can be interconnected with other veins, and connect with the intracranial veins, so that if an infection occurs in the skin, the bacteria will retrograde with the veins to enter into the cranium, and cause intracranial infections.