Sensodyne, known generically as Compound Aminophenol Alkylamine Tablets, is not recommended to be taken together with Cold and Flu, as both treat colds and their associated symptoms with overlapping ingredients, and taking them together can lead to an overdose. Cotrimoxazole tablets, which contain acetaminophen, amantadine hydrochloride, and chlorpheniramine maleate. It is used for the treatment of colds and their resulting headache, fever, malaise, and runny nose. Adverse reactions are nausea, vomiting, loss of appetite, etc. Rarely, mental confusion and leukopenia are seen. Contraindications are allergy to the product, peptic ulcer, pregnancy and lactation. Cold and Flu is a combination of Chinese and Western medicines, which contains trigonelline, gomme, chlorpheniramine maleate, acetaminophen and so on. It is used for antipyretic and analgesic treatment of cold and flu and its causes such as nasal congestion, sore throat and fever. Adverse reactions are occasionally seen rash, granulocytopenia, drowsiness and so on. Contraindications are severe hepatic and renal insufficiency. Colds should be timely to the hospital, under the guidance of the doctor to choose the appropriate drugs for treatment, not blindly use drugs, so as not to cause adverse consequences.