Whether the second recurrence of thyroid disease is curable or not needs to be decided according to the patient’s type of disease, personal constitution, and cannot be generalized. Hypothyroidism in the clinical generally can not be completely cured, need to follow the doctor’s advice long-term oral thyroxine tablets. For patients with hyperthyroidism who have been taking medication for a long period of time, it is recommended that they consult a doctor to adjust the dosage of the medication or the mode of treatment if there is a relapse. In case of relapse in patients with hyperthyroidism treated with iodine 131 or surgery, they can be treated with iodine 131 again or surgery. When the second recurrence of thyroid disease should be timely to the hospital endocrinology department, according to the patient’s specific condition treatment, to avoid delay.