Erythema nodosum refers to erythema nodosum, and hormone refers to glucocorticoids. Erythema nodosum may recur due to unregulated use of glucocorticoids. Erythema nodosum is one of a group of disorders known as nodular seborrheic dermatitis, which can be triggered by a variety of antigens including bacteria, viruses, and chemicals. Common triggers include streptococcal infections (e.g., rheumatic fever, scarlet fever) and tuberculous infections, and occasionally due to pneumonia, Mycobacterium avium pseudotuberculosis infection of the genus Yersinia, mycobacteriosis, cat-scratch disease, or medications. In acute exacerbations, active treatment of the primary disease (mainly streptococcal infections, rheumatism and tuberculosis), bed rest, avoidance of allergenic drugs, and internal administration of non-steroidal anti-inflammatory drugs, such as indomethacin and acetylsalicylic acid, should be carried out. Oral glucocorticoids are given if necessary to suppress the immune response. The disease is self-limiting and usually subsides naturally in 3 to 6 weeks with a good prognosis. However, if the infectious factors inducing erythema nodosum, such as tuberculosis infection, are not removed, it is easy to recur. If glucocorticoid treatment is not standardized for a long period of time, it may cause the infection to spread and lead to recurrence of erythema nodosum. Patients are advised to actively search for triggering factors to help reduce the number of episodes. When erythema nodosum reappears, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, and carry out targeted treatment or therapy under the doctor’s guidance.