Surgery is recommended for multiple gallstones, and laparoscopic cholecystectomy is generally recommended. Pharmacological treatment of multiple gallstones and lithotripsy are no longer recommended because of their inaccurate results. Surgery is the most commonly used treatment for multiple gallstones, and it is more necessary for those with more comorbidities and larger stones that cannot be discharged on their own. Surgery removes the gallbladder, and depending on the inflammation around the gallbladder during the operation, it is decided whether or not to put in a drainage tube, which is then removed after the drainage fluid has been drained out. Surgical treatment is not indicated for patients with underlying diseases or poor health. Patients with multiple gallstones need to be treated under the advice of a doctor. Seek medical attention if there is any discomfort.