Pain is no longer a simple symptom, but a disorder. (Chronic pain) The World Health Organization lists pain as the fifth major vital sign (breathing, pulse, blood pressure, temperature, pain). Pain is a subjective sensation and a protective response. This protective response is a reminder of what went wrong and how to avoid it next time. Rather than necessarily producing pain it is good. “Guan Gong scrapes the bones to heal” is so heroic, so male strong, but the reality of philosophy is that the hardest often collapse first (such as teeth and tongue contrast). Moderate stress can produce stress hormones (cortisol and catecholamines, etc.) to enhance the body’s tolerance, but excessive stress can produce inflammatory factors (interleukins, tumor necrosis factor, etc.) and lead to enhanced lipid catabolism and hyperglycemia, etc., thus bringing harm to autologous recovery. Advances in surgical medicine cannot be achieved without the regulation of stress by anesthesiologists. From local to general anesthesia, appropriate anesthetic drugs and modalities are selected according to the type of surgery, time, intensity of stimulation, etc. The patient benefits from this. Now we advocate more comfortable medical treatment, for example: gastroenteroscopy and fibrinoscopy treatment, imagine choking a grain of rice you are sad, let alone a catheteroscope placement ah! But with anesthesia you will be comfortable and complete the operation in your sleep, avoiding mental and physical trauma.