How long can you stop taking insulin and change to medication needs to be viewed in different situations, if it is type 1 diabetes or oral hypoglycemic drugs for poor control of type 2 diabetes patients need to be long-term or lifelong use of insulin therapy. If the acute complications of diabetes, such as ketoacidosis, type 2 diabetes mellitus patients to wait until the complications are relieved, or newly diagnosed type 2 diabetes mellitus patients after intensive treatment with insulin, you can follow the doctor’s advice to resume oral hypoglycemic drug therapy. Type 1 diabetes mellitus, due to the destruction of pancreatic B-cells leading to an absolute lack of insulin, usually through the injection of insulin to reduce glucose, so you need to use insulin treatment for a long time or for life; and patients with type 2 diabetes mellitus who can not be well controlled by oral hypoglycemic drugs also need to use insulin treatment for a long time or for life; therefore, it is not recommended to discontinue the use of insulin. Patients with type 2 diabetes mellitus with acute ketoacidosis can be cured in 2~3 days after standardized treatment, while severe cases may take 7 days or longer, and when the blood glucose returns to the previous level after the acute complications are relieved, oral hypoglycemic drugs can be used instead according to the actual situation. Newly diagnosed type 2 diabetes mellitus patients are treated with intensive insulin therapy for about 7 to 14 days, and after the blood glucose is stabilized, it can be changed to oral hypoglycemic drugs or continue to apply insulin therapy according to the actual situation. Patients who are not sure how long insulin can be replaced by oral hypoglycemic agents are advised to go to regular hospitals and consult professional doctors, and not to adjust the treatment plan without authorization, in order to avoid acute complications and life-threatening conditions.