High total bilirubin and direct bilirubin are related to factors such as hepatobiliary damp heat, chronic active hepatitis, and obstruction of the biliary system. There are many causes of high total or direct bilirubin in humans, and the common ones are physiological factors, such as frequent alcohol consumption, strenuous exercise, pregnancy, obesity and other factors. When high bilirubin occurs, it is mainly considered to be directly related to damp heat in the liver and gallbladder, which can lead to dysfunction of the liver and gallbladder, and patients may also experience abdominal distension and pain, nausea, vomiting, fever and other manifestations. In the presence of chronic active hepatitis, the person will experience hepatosplenomegaly, abdominal distension, physical weakness, etc. When liver function tests are performed in the hospital, direct or total bilirubin will also be high. Patients with obstruction of the biliary system, such as bile duct stones and secondary bile duct stones, can cause pain in the right upper abdomen, which can lead to worsening of symptoms when overeating and eating cholesterol-based foods, and indirect elevation of total bilirubin during hospital tests.