Glioma belongs to a kind of malignant tumor, which is difficult to treat, so it is not good to cure, and glioma is easy to recur, resulting in the decline of patients’ survival rate. At present, with the continuous development of neuroimaging technology and microsurgery technology, it has played a great role in promoting the surgical treatment of glioma, and it provides a better guarantee for the total excision of glioma, and with the continuous deepening of molecular biology, it also provides a broad prospect for the gene therapy of tumor. At present, surgery is the first choice for the treatment of glioma, with total excision as far as possible during surgery, and combined with radiotherapy, chemotherapy, biotherapy and other comprehensive treatments after surgery. It is very helpful to improve the survival rate of patients.