Esophageal squamous epithelial simple hyperplasia is mostly caused by poor dietary habits. The same disease, the patient’s physical condition is different, different stages of the disease, the treatment method is different. Esophageal squamous epithelial simple hyperplasia belongs to the benign lesions of the esophagus, usually reflux esophagitis, bad dietary habits, such as frequent consumption of spicy and stimulating diets, love to eat hot food, etc., the emergence of dysphagia, nausea and other symptoms. If it is mild hyperplasia, dietary attention should be paid to avoid spicy stimulating food, and hard food, avoid drinking alcohol, do not eat hot food and so on. It is recommended to take acid suppressants, gastric mucosal protectants, such as omeprazole, bismuth potassium citrate and other drugs under the guidance of a doctor. If it is moderate or severe hyperplasia, it is necessary to exclude the possibility of precancerous lesions of esophageal cancer. It is necessary to go to the hospital for further consultation, according to the specific condition, to decide the treatment plan, and if necessary, to carry out surgical treatment. The above drugs have allergic and other adverse reactions, avoid self-medication. Standardized treatment should be carried out under the guidance of doctors.