One capsule a day long-term service omeprazole may be atrophic gastritis, osteoporosis-related fractures and other side effects of harm, specific instructions for use. Omeprazole can block the secretion of gastric acid, is commonly used in clinical proton pump inhibitors, suitable for the treatment of reflux esophagitis, peptic ulcer (gastric, duodenal ulcer), Droe-Ayer’s syndrome (gastrinoma), need to be prohibited for those who are allergic to the product, and lactating women, hepatic and renal dysfunction of the group should be cautious use. Adverse reactions such as headache, diarrhea, constipation, abdominal pain, nausea, vomiting, bloating, acid reflux, upper respiratory tract infections, dizziness, fatigue, back pain, cough, and skin rashes may occur with the use of the drug. The drug is generally not recommended to be taken for a long period of time, while long-term use of the drug may increase the probability of certain symptoms or diseases, such as the occurrence of atrophic gastritis, gastric mucosal cell hyperplasia, osteoporosis-associated fracture, hypomagnesemia, and Clostridium difficile-associated diarrhea. Specific medications should be administered under the guidance of a specialist.