High creatinine on physical examination for several years in a row is considered to be chronically elevated, and the etiology is commonly found in chronic renal failure, which is relatively serious at this time; however, there is also a possibility that it is physiologically elevated, such as in muscular athletes, which is not a serious condition and is a normal phenomenon. Creatinine is a product of muscle metabolism and is a good indicator of glomerular filtration function because it can be completely filtered from the glomerulus with little tubular secretion or reabsorption. The common causes of chronic renal failure are glomerulonephritis, nephrotic syndrome, hypertensive nephropathy, diabetic nephropathy, etc. After clarifying the specific causes of the disease, timely and standardized treatment, and at the same time, usually do not eat spicy and stimulating, too oily food, can not be tired to stay up all night, to maintain a good routine. This kind of situation is more serious, the condition may develop into uremia. Physiological conditions such as muscular athletes, due to the muscle metabolism is vigorous, creatinine can be elevated without other uncomfortable symptoms of performance, this time is not serious, generally no treatment, regular review can be. It is recommended that patients with elevated creatinine go to a regular hospital in a timely manner to find out the cause of the problem and follow the doctor’s instructions for standardized treatment.