The main side effect of Semen Nelumbo is that it is bitter and cold and hurts the stomach. It is bitter and cold in nature, so it is often used to treat mania, skin sores and swelling, and snake bites caused by internal disturbances of heat and toxicity. In addition, it can stop bleeding and resolve bruises, and is used to treat local bruises caused by trauma and bruises. It can also promote water retention and reduce swelling, treating ascites caused by liver cirrhosis and liver cancer, and is often used in combination with half a lotus and zedoary. However, due to its bitter-cold nature, it should be used with caution for people with blood deficiency and pregnant women. Because bitter cold damages the spleen and stomach and is not conducive to the spleen’s and stomach’s transportation, it may cause indigestion, indigestion, abdominal distension and diarrhea, etc. Blood deficiency may aggravate dizziness and weakness, and pregnant women may have premature delivery and slippery fetus, so it must be used with caution.