A blood creatinine of 105 μmol/L is near the upper limit of normal or mildly elevated. Normal serum creatinine values range from 53 to 106 μmol/L in adult males and from 44 to 97 μmol/L in females. Therefore, a blood creatinine of 105 μmol/L is near the upper limit of normal or mildly elevated. Creatinine is an indicator that reflects the filtration function of the kidneys, and its normal value has a greater relationship with age and gender. In adults, as the glomerular filtration rate gradually decreases with age, the normal value of creatinine will gradually increase, and the normal value of creatinine in men is slightly higher than that in women. Mild excess creatinine may be caused by physiological reasons, such as strenuous exercise, eating a lot of high-protein food, fever and so on, which can cause creatinine to rise transiently. Pathologic causes are more common in acute kidney injury and chronic renal insufficiency. Creatinine alone cannot reflect the real renal function, because the kidney has a strong compensatory ability, only when the glomerular filtration rate decreases more, the creatinine will increase. In this case, it is necessary to combine with cystatin C, urine routine and other related tests to make a comprehensive judgment. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.