50-year-old woman leg pain and weakness, the main reason to consider with excessive fatigue, osteoporosis, joint lesions, lumbar spine lesions and so on. 1. Excessive fatigue: If a 50-year-old woman usually long time weight-bearing exercise, it is easy to produce the feeling of excessive fatigue of the lower limbs, thus triggering the performance of leg pain and weakness, generally appropriate rest after the symptoms will be relieved. 2. Osteoporosis: 50-year-old woman into the perimenopause, estrogen levels dramatically reduced, prone to osteoporosis, resulting in leg pain and weakness and other symptoms. 3. Joint lesions: 50-year-old women who suffer from degenerative knee joints, rheumatoid arthritis, etc., can appear leg pain and weakness symptoms. 4. Lumbar spine lesions: 50-year-old women who have lumbar spine lesions oppressing the sciatic nerve can experience symptoms of leg pain and weakness. Lower extremity peripheral nerve injury or the existence of central nervous system lesions, easy to affect the limbs of the motor and sensory functions, resulting in leg pain and weakness and other symptoms. Leg pain and weakness in a 50-year-old woman can also be caused by other diseases, including varicose veins in the lower limbs, arterial embolism and diabetes complications. It is recommended to consult a doctor in time to check the cause of the disease and then carry out targeted treatment under the guidance of a professional physician.