Neonates with third-degree amniotic fluid contamination can be discharged from the hospital after 3 to 7 days of observation if there are no abnormal signs; if there are severe symptoms such as asphyxia, vomiting, cyanosis, etc., they need to be hospitalized for observation and treatment, ranging from as short as one week to several weeks in severe cases. Neonatal amniotic fluid third-degree contamination may lead to neonatal asphyxia, meconium aspiration syndrome, etc., and some newborns do not have abnormal manifestations, so its observation time depends on whether the newborn is combined with asphyxia as well as meconium aspiration syndrome, and the observation time is not the same. If the neonate has no abnormal signs after the third-degree amniotic fluid contamination, and the temperature, breathing, feeding and defecation are normal, the neonate can be discharged from the hospital with the mother after 3 to 7 days of observation. If the newborn’s amniotic fluid is contaminated with severe asphyxia, vomiting, cyanosis and other symptoms, it is necessary to be hospitalized for observation and treatment, as short as one week, or in severe cases, it will take several weeks, and when the condition improves, the newborn can be discharged from the hospital after being taken off oxygen. Specific cases need to follow the doctor’s treatment arrangements.