Hepatitis B immune tolerance period refers to high viral load, generally hepatitis B HBV-DNA > 10^7 IU/ml, but the patient’s liver function is normal and liver puncture can reveal no inflammation or only slight inflammation of the liver. At this time, if the patient applies antiviral drugs, the organism cannot achieve the antiviral efficacy very well. Only when the body enters the immune clearance period, the application of antiviral drug therapy can achieve better efficacy. Chronic hepatitis B HBV-DNA infection is generally divided into four periods, namely the immune tolerance period, the immune clearance period, the immune control period, and the infection period.