Currently there are many people who need to undergo craniotomy because of a traumatic brain injury due to an accident, and after craniotomy, some patients have cranial defects. Cranial defect has a great impact on health because the skull is an important umbrella for brain tissue, and once the skull is defective, the brain tissue lacks protection and is easily attacked by the outside world. After skull defect, it is very necessary to do skull repair surgery, but patients should seize the better time to repair, so as to recover better. Generally speaking, if a patient has a giant cranial defect caused by decompression of the large bone flap for cranial hypertension, he or she must undergo cranial repair surgery 3 months after the surgery, which is a better time. However, in addition to the timing, the choice of cranial repair material is also very critical, as the material directly affects the success or failure of the surgery. From ancient times to now, there are many materials used for skull repair, such as bone cement and animal bone in the early days, but they have been eliminated long ago because of various defects. And now most of the hospitals are using titanium mesh material, which is much more progressive compared with the traditional material, but there are some inevitable problems, and patients should choose carefully. According to the survey, the more ideal material for skull repair surgery is polyether ether ketone PEEK material, which is an advanced polymer material, safer than titanium mesh material, its various properties are excellent, and even comparable to the autologous skull, choose this material for skull repair surgery is more than good.