Diverticula of the colon usually have no obvious symptoms, and those who have symptoms may show abdominal pain, abdominal distension, fever and changes in bowel habits. Patients with simple diverticula without discomfort do not need treatment. If the symptoms of diverticulitis appear, antibiotic anti-infection treatment can be chosen, and surgery is feasible when necessary. Diverticulum of the colon refers to the outward projection of the wall of the colon to form a pouch, and the vast majority of patients do not have symptoms, and those who have symptoms usually start from mild abdominal pain, abdominal distension, and gradually develop to perforation, and sepsis and peritonitis, which manifests itself as abdominal pain, fever, constipation, diarrhea, abdominal distension, nausea, vomiting and other symptoms. Patients with simple diverticula without uncomfortable symptoms usually do not need treatment, and regular follow-up review is sufficient. If the symptoms of diverticulitis appear, antibiotic anti-infection treatment can be chosen, commonly used drugs are cefoxitin, ampicillin and so on. If antibiotic treatment is ineffective, or diverticulitis recurs, or combined with perforation, obstruction and other serious complications, it is recommended to surgically remove the diseased colon. Patients with colonic diverticulosis should pay attention to it and seek timely medical attention for further management or treatment under the guidance of a doctor, and medications should be used as prescribed by the doctor.