Pathologic jaundice mostly refers to neonatal pathological jaundice. Causes of pathologic jaundice include neonatal hemolytic disease, neonatal sepsis, and so on. The treatment methods are different according to the causes. 1. Neonatal hemolytic disease: it refers to immune hemolytic disease caused by the difference of blood type between mother and child, manifested by jaundice, anemia, edema and so on. The treatment is to correct anemia, electrolyte disorders, give oxygen, prevent the newborn’s body temperature from dropping, etc., but also can be injected with immunoglobulin, light therapy and so on. 2. Neonatal sepsis: an infectious disease in which the pathogen enters the blood circulation and rapidly grows and reproduces, causing systemic inflammation. The manifestations include jaundice, hepatosplenomegaly, hemorrhage and even shock. Treatment is given antibacterial treatment, such as benzoxicillin, vancomycin, etc., also can be injected with immunoglobulin, and severe neonates can be treated with blood purification if necessary. It is recommended that you should actively seek medical attention and follow the doctor’s instructions for medication and treatment.