Ischemic-hypoxic encephalopathy caused by pulmonary embolism can be treated by supportive therapy, controlling convulsions, eliminating cerebral edema and subcooling therapy. 1. Supportive therapy: maintain good ventilation, ensure that the oxygen saturation of patients is more than 60~80 mmHg, and patients with hypotension can follow the doctor’s instructions to use dopamine, dobutamine and other drugs to maintain blood pressure and ensure cerebral perfusion. 2. Control convulsions: Convulsions are a common symptom of ischemic-hypoxic encephalopathy, and can be treated with anticonvulsant drugs such as phenobarbital and midazolam. 3. Eliminate cerebral edema: avoid excessive infusion, cerebral edema will cause intracranial pressure to rise, affecting the recovery of patients with ischemic-hypoxic encephalopathy. Furosemide, mannitol and other drugs can be used to help eliminate cerebral edema as prescribed by the doctor. 4. Sub-hypothermia treatment: Artificial induction method to lower the hypothermia by 2~5℃ to reduce the energy consumption and oxidation reaction of the brain, so as to achieve the effect of protecting the brain cells. Patients with ischemic-hypoxic encephalopathy caused by pulmonary embolism should go to the hospital in time and be treated as soon as possible with the help of doctors, and the prognosis of early treatment is better.