Generally, itchy palms at night in bed may be caused by eczema, urticaria, diabetes and other reasons. 1. Eczema: Eczema can be caused by a variety of reasons, such as mental stress, fatigue, climate change, animal fur and other stimuli. When eczema grows on the palms of the hands, itchy palms can occur. 2. Urticaria: in the middle of the night, such as a sudden breakout of urticaria in the palm of the hand, can appear itchy palms, localized wind masses and other symptoms. Generally due to capillary dilatation, osmotic increase caused by local edema caused by the symptoms. 3. Diabetes: diabetic patients with high blood sugar caused by metabolic disorders, nutrient nerve microvascular damage, neurotrophic disorders, resulting in neuropathy, skin itching can occur, which may appear at night sleep palms itchy phenomenon. In addition, itchy palms at night can also be seen in other diseases, it is recommended that patients go to the hospital in a timely manner, to clarify the cause of the disease and follow the doctor’s instructions for treatment.