Insulin resistance is mainly manifested as acanthosis nigricans, obesity, irregular menstruation, easy fatigue, abnormal sexual function, etc. The performance of different individuals may be different, and some patients may have no obvious symptoms. 1. Acanthosis nigricans: it is the characteristic skin damage of insulin resistance, which is manifested as brown, velvety, hyperkeratotic plaques in the folds. 2. Obesity: centripetal or abdominal obesity and ectopic fat deposition are common, which may increase the risk of atherosclerosis, cardiovascular and cerebrovascular diseases, polycystic ovary syndrome and other diseases. 3. Sex hormone abnormalities: may lead to irregular menstruation, amenorrhea, hirsutism, abnormal sexual function and other manifestations. There are many symptoms of insulin resistance, but you can’t diagnose and treat it simply based on the symptoms, it is recommended to go to the hospital in time, and get a clear diagnosis and standardized treatment under the guidance of the doctor.