There is no universally recognized conclusion on the three most serious medicines that harm the kidneys. It is usually believed that Guanmutong, Han Fangji and Chuanwu harm the kidneys. 1. Guanmutong is the vine and stem of the Aristolochiaceae plant, Aristolochia northeasternica, which contains aristolochic acid that is toxic and can cause acute kidney failure and severe death if used in excessive amounts. Vomiting, edema, urinary urgency, confusion, and chest tightness may generally occur after taking it. At present, our country has discontinued the drug Guanmutong, and generally use Mutong or Chuanmutong. 2. Guangpuji is the root of Aristolochiaceae plant Guangpuji, which contains aristolochic acid with nephrotoxicity, so it can not be used at present, and clinically, generally use the powdered Fangzhi. 3. Chuanwu is the root of buttercup plant aconite, which contains aconitine, improper decoction can damage the kidney, generally need to be decocted for about 1 hour to prevent poisoning, kidney function abnormalities are not recommended. Nationally banned drugs can not be taken, the pharmacopoeia allows the use of the need for medical guidance to take.