Retrograde ejaculation generally refers to reverse ejaculation, which is mostly considered to be related to congenital factors, medical factors, drug factors, mechanical factors and disease factors. 1. Congenital factors: usually congenital wide bladder neck, congenital spina bifida, congenital urethral valves, congenital urethral diverticulum, etc., will lead to incomplete closure of the bladder neck, and also increase the resistance of the urethral membrane, which can cause reverse ejaculation. 2. Medical factors: usually when patients undergo bladder neck and prostate surgery, retroperitoneal extensive lymph node dissection, thoracolumbar sympathectomy, etc., the nerve roots will be damaged or removed, resulting in incomplete closure of the bladder neck and retrograde ejaculation. 3. Drug factors: after taking adrenergic receptor blockers such as rifampicin, methythiopyridazine hydrochloride, and brompheniramine, all of them can cause smooth muscle contraction weakness, which can also induce the phenomenon of reverse ejaculation. 4. Mechanical factors: reverse ejaculation is also related to trauma, inflammatory urethral stenosis and other factors, mainly due to increased urethral resistance, resulting in semen obstruction. For patients with long-term urinary difficulties, there may also be a decrease in bladder neck tension, leading to its weak closure. 5. Disease factors: generally diabetic patients can be complicated by reverse ejaculation, while spinal cord injury, urethritis, bladder stones, cystitis and other diseases will lead to the phenomenon of reverse ejaculation, and some patients may also lose the ability to ejaculate. It is recommended that when patients experience reverse ejaculation, the cause of the disease should be clarified in a timely manner and targeted treatment should be carried out in accordance with the doctor’s instructions.