If the patients themselves do not have serious liver or kidney damage, antihypertensive drugs generally do not cause much damage to the liver or kidneys. If severe liver or kidney insufficiency exists, antihypertensive drugs need to be strictly screened to avoid further aggravating the burden on the liver and kidneys. Although most antihypertensive drugs have some side effects, such as angiotensin converting enzyme inhibitor antihypertensive drugs, such as captopril and enalapril, which may cause irritating dry cough, diuretics, such as hydrochlorothiazide and indapamide, which may cause lowering of blood potassium. However, they seldom affect and harm the liver and kidney functions of patients, and the above side effects can be effectively avoided after taking them in quantitative and regular doses according to the doctor’s instructions and adjusting the types of antihypertensive drugs in a timely manner. However, it should be noted that severe hepatic and renal insufficiency, due to drug metabolism obstacles, the choice of antihypertensive drugs is limited, antihypertensive program must be combined with the liver and kidney function, as well as the patient’s overall physical condition of the formulation. In general the benefits of taking antihypertensive drugs outweigh the disadvantages, if the blood pressure is not effectively controlled, it may aggravate the damage to the heart, brain, kidney and other blood vessels. In addition, antihypertensive drugs need to be taken in accordance with the doctor’s instructions, and timely communication with the doctor after taking medication, according to the situation to adjust the medication.