Itchy ankles and wrists with small red bumps consider eczema, insect bite dermatitis, atopic dermatitis and other diseases caused. 1. Eczema: the cause of eczema is not yet clear, mainly related to genetics, immune abnormalities, hormone level changes, etc., the patient’s acute phase manifested as erythema, edema, papules, papules, etc., conscious itching. Happens on the head and face, hands, feet and distal limbs, etc., was symmetrically distributed. 2. Insect bite dermatitis: Insect bite dermatitis is an allergic reaction to insect bites, which is characterized by skin lesions and itching at the bite site. If the ankle is bitten by mosquitoes, there will be itchy red bumps on the ankle. 3. atopic dermatitis: itchy red bumps on the ankles and wrists may also be caused by atopic dermatitis, atopic dermatitis is typically manifested as eczema-like rashes, intense itching, etc., is genetic, immune abnormalities and skin barrier function abnormalities caused by the ankles and wrists. There are more reasons for itchy red bumps on the ankles and wrists (such as urticaria, common itchy rash, etc.), and it is recommended to consult a doctor for a clear diagnosis.