Citalopram oxalate tablets are generally not resistant after taking them for a long time. Citalopram oxalate tablets are 5-hydroxytryptamine reuptake inhibitors, is a more commonly used in clinical antidepressant drugs, at present, according to the existing preclinical as well as clinical evidence does not show that this type of drug can lead to dependence, therefore, long-term medication as long as the dosage is taken in accordance with the doctor’s dose, the general will not produce drug dependence. Although escitalopram oxalate tablets generally do not lead to drug resistance, they are not recommended for long-term use, as they may lead to a number of adverse effects, the more common of which are decreased liver function and decreased kidney function. Escitalopram oxalate tablets should always be directed by a doctor, and should not be used arbitrarily, especially not to reduce, stop or increase the dosage.